Valon Morina*, Arta Bilalli, Ermira Salihu, Kreshnik Kastrati, Marigonë Krasniqi and Medina Haxhimurat
The relationship between serum 25-OH Vitamin-D level in hypothyroid patients with and without thyroid peroxidase (TPO) antibodies is controversial. There is growing evidence that the level of Vitamin-D 25-OH is related to autoimmune diseases. The study aimed to evaluate the relationship between serum Vitamin-D levels and thyroid function tests in euthyroid and hypothyroid patients from Pristina with (anti -TPO) raised. Cross-sectional analyzes were conducted at H.P Diagnostic Center, American Hospital and Olive Laboratory from February to June 2023. Fifty patients with hypothyroidism were selected. Another fifty were chosen as the control group. The tests of (TSH, FT4, Anti-TPO, Vitamin-D 25- OH) were measured using COBAS E 411 system analyzer. The results were analyzed using SPSS version. TSH was significantly increased in both hypothyroid patients with positive TPO antibodies (7.75±10.34) and negative TPO antibodies (5.01±0.79) compared to the control group (2.69±1.33), respectively, with a p -value of 0.560. The level of 25-OH Vitamin-D was lower among hypothyroid patients than in the control group. TPO-antibody-positive subjects had lower 25-OH Vitamin-D levels (10.38±4.45), than TPO antibody-negative patients (18.79±8.93) compared to controls (64.92±161.08), respectively, with the p-value value 0.045. In hypothyroid patients, women 34 (68%) were more than men 16 (32%).
Conclusion: The level of Vitamin-D 25-OH was low in patients with hypothyroidism. TPO- antibody-positive subjects had less serum 25-OH Vitamin-D compared to TPO-antibody- negative subjects.
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