Zeitschrift für Neurologie und Neurowissenschaften

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Central and Extra Pontine Myelinolysis in the Setting of Hyperglycemia

Mohammad Siraj Qadir1, Muhammad Ubaid Hafeez1*, Adeeba Sheikh1, Komal Hafeez1, Aaron Desai1, Mohammad I. Hirzallah1

Osmotic demyelination syndrome (ODS) was first described by Adams et al. in 1959 as a combination of quadriparesis, pseudobulbar paralysis, and the distinctive myelin loss in the pons, attributable to alcoholism or malnutrition.[1] ODS has since been commonly attributed to rapid correction of chronic hyponatremia. Other reported etiologies include alcohol withdrawal, liver transplantation, hypokalemia, hypernatremia as well as severe hyperglycemia. [2-6] (e1-20) Here, we describe a case of ODS associated with diabetic ketoacidosis (DKA) and review the existing literature on hyperglycemia-related ODS.