Gurpreet Singha1, Palak Jhamba1, Mehak Bhata1, Sankar Ramakrishnan2, Kaisar Razac3 , Amita Sarwala1
he Blood-Brain Barrier (BBB) acts as a hindrance to the transport of potential therapeutic agents in the brain; hence it serves as a major limiting factor to treat pharmacological dysfunction of the central nervous system (CNS). In a healthy brain, the BBB act as an essential barrier for protecting normal brain functions by preventing the transportation of foreign substances from the systemic circulation into the brain.
Area covered
This review gives us complete knowledge of the anatomical structure of the BBB and mechanisms involved in drug transport. It highlights the major aspects to be considered for the effective brain delivery of the drugs. It has also covered different types of barriers that obstruct the entry of therapeutic agents as well as the current strategies and approaches that facilitate penetration across the barrier for enhanced drug delivery to the CNS.
Expert opinion
There is a need for an in-depth understanding of the physiochemical activity of the carriers used, pharmacokinetic properties of the therapeutics required to be delivered, as well as the anatomical and biological factors which have an immense influence on the delivery of the drugs to the brain.
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