Ahirrao Sapana P*, Bhambere Deepak S, Patil Moreshwar P, Kshirsagar Sanjay J, Kanade Rupali N and Udavant Pavan B
Introduction: Mucoadhesives are synthetic or natural polymers, which interact with the mucus layer covering the mucosal epithelial surface and mucin constituting the major part of the mucus. The use of a mucoadhesive dosage form for drug delivery via the gastrointestinal mucosal route increases bioavailability and results in a longer therapeutic impact. Migraine is a prevalent headache illness that places a significant financial and social burden on both the patient and society. It is a puzzling condition characterized by pulsating headaches that are usually limited to one side and occur in bouts lasting 4 to 48 hours and is often associated with nausea, vomiting, sensitivity to light, vertigo, loose motions and other symptoms.
Material and Methods: The Rizatriptan is a selective 5- hydroxytryptamine receptor subtype agonist acute treatment of migraine attacks with or without aura in adult. Mucoadhesive film was prepared by solvent casting method. In this way, gastric mucoadhesive drug delivery system can delay the retention time of a dosage form in the stomach, consequently working on the oral bioavailability of the medication and decrease in dosing recurrence.
Results: All batches showed low dissolvability of polymer since ethyl cellulose eudragit RLPO isn't solvent in water so film was not satisfactory and low collapsing perseverance which prompted film with helpless pliancy and versatility. Out of all cluster, showed great adaptability, collapsing perseverance, high expanding list, mucoadhesive strength and medication discharge so this group was chosen as ideal for factorial design.
KeywordsMigraine; Rizatriptan; Gastro retentive film; Mucoadhesion; Solvent casting method; Ethyl cellulose; Eudragit RLPO
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