English Spanish Chinese Russian French Japanese Portuguese Hindi Telugu Tamil

Internationale Zeitschrift für Arzneimittelentwicklung und -forschung

  • ISSN: 0975-9344
  • H-Index der Zeitschrift: 44
  • Zitierbewertung der Zeitschrift: 59.93
  • Journal-Impact-Faktor: 48.80
Indiziert in
  • Genamics JournalSeek
  • Nationale Wissensinfrastruktur Chinas (CNKI)
  • CiteFactor
  • Scimago
  • Verzeichnis der Indexierung von Forschungszeitschriften (DRJI)
  • OCLC – WorldCat
  • Publons
  • MIAR
  • Kommission für Universitätsstipendien
  • Euro-Pub
  • Google Scholar
  • SHERPA ROMEO
  • Geheime Suchmaschinenlabore
  • ResearchGate
Mehr sehen
Teile diese Seite

Abstrakt

Effect of Particle Size of Nonsteroidal Anti-Inflammatory Drug on Lipopolysaccharide-Induced Inflammation on RAW264.7 Cells

Junko Yokota, Shiro Ishida, Atsuhide Hamada and Shojiro Kyotani

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) have excellent anti-inflammatory and analgesic effects and are widely used in inflammatory diseases. In this study, mouse macrophage cells stimulated with Lipopolysaccharride were used as a model experiment to investigate the influence of NSAIDs particle size on the inflammatory response. Methods: RAW264.7 cells were used in this study. RAW264.7 cells, the survival rate was measured using the MTT method. Inflammation caused by using Lipopolysaccharride. The NSAIDs used were Indomethacin (IMC), ketprofen (KET), piroxicam (PXC), three kinds, and the antiinflammatory effect on the bulk powder and nano particles was evaluated. Evaluation of inflammation was based on inflammatory cytokines (IL-6, TNF-a) and NO production. Results: NSAID nano showed significant inhibitory effect on inflammatory cytokines (IL-6, TNF-a) and NO production compared with NSAIDbulk However, in NSAIDs with each particle size, no difference was found between the three drugs. Conclusion: This suggests that the NSAIDnano preparation may be a raw material for new drugs. In addition, it was suggested that NSAIDnano preparation could reduce the concentration of the drug.

Haftungsausschluss: Dieser Abstract wurde mit Hilfe von Künstlicher Intelligenz übersetzt und wurde noch nicht überprüft oder verifiziert