Dr. Nabaneeta Mahata
Nonalcoholic fatty liver disease is a chronic liver disease with prevalence 9-40 percent in different areas of the world. It is estimated that it will become the most common cause for liver transplantation in the coming years. The major causes implicated for fatty liver who consume no or minimal alcohol are toxins environmental like carbon tetrachloride, ethionine, hepatitis B and C, chemicals like insecticides, pesticides, excess fat diet or defective nutrition like protein deficiency, essential nutrient deficiency like vitamin B 12, choline, methionine. In this research biochemical parameters like fasting glucose, insulin, Kidney function tests, liver function tests, lipid profile, serum electrolytes, total proteins and albumin, LDH and others were measured. Two novel biomarkers Adiponectin and Leptin were also measured with Enzyme linked immunosorbent assay. The extent and severity of these biochemical markers were statistically correlated with fibroscan, an established imaging study of liver which quantifies the extent of fatty infiltration called steatosis expressed in kilopascals and controlled attenuated parameters CAP expressed in decibels per meter. The study showed that there may be a correlation of these parameters with disease severity especially of Adiponectin. It may also be used as a therapeutic target in NAFLD.
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