Bijan Riazi Farzad, Saeed Safari, Maral Jafarpour, Fatemeh Ramezani and Atousa Janzadeh
Objective: Precision medicine has become a hyped topic since most of the attention is on the diverse nature of each individual which results in different responses to the same medicine.
Literature review: We have reviewed different factors from socio-economical to genetic and epigenetic factors and how they potentially impact the person's body to react. We have reviewed over 100 studies on probable contributed factors of personalized medicine. And also we have provided guideline and solutions to achieve our goal of Precision Pain Medicine (PPM). Studies show epigenetic factors such as stress, alcohol consumption, depression, and have an eminent role. Stress can affect pain threshold, changes in loco-motor activity, body temperature and catalepsy. Having qualified devices, medication, physician perspective, genetics and even age are influential as well. A road-map has been provided as well to form a global network of PPM.
Conclusion: Our study showed that besides genetics, epigenetic, cultural and political and also plays an important role in PPM. There are many obstacles in the way as well; one of the most prominent setbacks in the progression of PPM is political issues. We have yet a long way to fill blind spots to complete our knowledge.
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