English Spanish Chinese Russian French Japanese Portuguese Hindi Telugu Tamil

Zeitschrift für Universalchirurgie

  • ISSN: 2254-6758
  • H-Index der Zeitschrift: 8
  • Zitierbewertung der Zeitschrift: 1.33
  • Journal-Impact-Faktor: 1.34
Indiziert in
  • Genamics JournalSeek
  • Verzeichnis der Indexierung von Forschungszeitschriften (DRJI)
  • OCLC – WorldCat
  • Euro-Pub
  • Google Scholar
  • SHERPA ROMEO
Mehr sehen
Teile diese Seite

Abstrakt

Prophylactic dexamethasone in pediatric open heart surgery PTX3 blood pentraxin elevations: Potential clinical significance

Prigione Ignazia

Administration of glucocorticoids before Cardio Pulmonary Bypass (PCB) may reduce the systemic inflammatory response and improve clinical outcomes. Pentraxin long PTX3 is a novel inflammatory parameter that may play a cardioprotective role by modulating inflammation. 29 children undergoing open heart surgery were enrolled in the study. Fourteen children received dexamethasone (first dose 1.5 mg/kg IV or IM one day before surgery; second dose 1.5 mg/kg IV before initiating bypass surgery) and fifteen children were used as controls. Blood PTX3, short C Reactive Protein (CRP), Interleukin-1 Receptor II (IL-1RII), fibrinogen, and Partial Thromboplastin Time (PTT) were measured at different time points. PTX3 levels were significantly increased during CPB in both Dexamethasone (+D) and Dexamethasone (-D)-treated and Non-Dexamethasone (-D)-treated subjects, but were significantly higher in +D than in -D patients. . CRP levels were significantly increased in both +D and -D patients in the postoperative days, with values significantly higher in -D patients than in +D patients. Fibrinogen and PTT values were significantly higher in -D patients than in +D patients on the first postoperative day.

Haftungsausschluss: Dieser Abstract wurde mit Hilfe von Künstlicher Intelligenz übersetzt und wurde noch nicht überprüft oder verifiziert