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Abstrakt

TH588 Potently Kills Melanoma Cells Grown in 3-Dimensional Culture Through Apoptosis Induced by ROS

Jia Yu Wang, Chen Chen Jiang, Xu Guang Yan, Lei Jin and Xu Dong Zhang

MutT homolog 1 sanitizes oxidized dNTP pools through converting 8-oxo-deoxy-guanine (8-oxo-dGTP) and 2-OHdeoxy- adenosine (2-OH-dATP) into the corresponding monophosphates, thus protecting cells from DNA damage caused by reactive oxygen species (ROS).