When the substrate binds to water then that interaction is known as hydrophilic interaction and the contact angle between water and substrate will be very less.
Molecules that have charged parts to them are attracted to the charges within the water molecule.
Related Journals of Hydrophilic interactions
Journal of Developing Drugs,Drug Designing: Open Access, International Publisher of Science, Technology and Medicine, Advanced Drug Delivery Reviews, American Journal of Drug Discovery and Development, Arzneimittel-Forschung/Drug Research, Assay and Drug Development Technologies, Biopharmaceutics and Drug Disposition, Cardiovascular and Hematological Disorders - Drug Targets,Chemical Biology and Drug Design, Clinical Pharmacology in Drug Development, Critical Reviews in Therapeutic Drug Carrier Systems, Current Cancer Drug Targets, Current Drug Delivery, Current Drug Targets.